Defect or disease from birth

 Chronic or terminal disease

 Hurt or disabled in an accident

 Poverty (since birth or later in life)

 Loss of parent

 Loss of child

 Child Abuse (ongoing or single incident)

 Broken home/Domestic strife

 Feeling unwanted - unloved - "thrown away"/foster child - adopted (even by non-caring family)/felt used by "the system"

 I don't want to talk about it

 None. I have had a good life